Why IVF treatments don’t work in certain cases?

ARC International Fertility & Research Centre belongs to the best fertility clinic in India, therefore we asked their specialists to tell us why IVF treatments sometimes do not work.

A failed IVF cycle can unleash an overwhelming torrent of emotions. Going into the cycle, you felt anticipation and building excitement, hoping this will be when your family starts, and worry at the same time. Will it work?  When a cycle fails, you and your partner may feel disappointed and even very angry. What went wrong? Is it someone’s fault that IVF didn’t work? Should you try again? It’s normal to grieve for this loss, but try not to blame yourself or your partner.

Common reasons why an IVF cycle fails

1. Lifestyle

  • Maintain a healthy weight. Losing as little as 10 per cent of total body weight can make a positive difference in one’s ability to conceive.
  • Eat healthy and fresh food. Eat a lot of vegetables and fruits. Avoid fried and processed foods.
  • Exercise regularly.
  • Men and women should refrain from alcohol and smoking.
  • A good sound uninterrupted sleep of 8 hours is required.
  • Relaxed and calm mind.

2. Embryo Quality

The quality of embryo also plays a major role in the success of an IVF cycle. If the embryo quality is not very good, then chances are very small. The embryo might not have the capability to grow after it has been kept in a good environment. Embryo quality can be assessed by PGD/PGS.

3. Age of the female partner

Age plays a major role in a female partner as it determines the quality of oocytes which in turn determines the quality of the embryo. Younger age women  (<30yrs) produce the better yield of oocyte than elderly. Elderly women are more prone to having chromosomal issues.

4. Quality of sperms

Again the quality of sperms also plays a vital role. A good semen analysis and a sperm fragmentation test will give the real prove if the sample is good enough for the high-quality embryo.

5. Uterine factors

If the female partner has problems like fibroids or polyps, these have to take care before the embryo is transferred. Surgical removal can be planned for these patients.

6. Uterine lining issues

In some patients, repeated implantation failure can occur, even in spite of transferring good embryos. This condition is known as implantation failure and can be further confirmed by ERA testing, where the lining is sent for receptivity screening and analysis.

Hence by further analysis of all these factors, we can prevent further failures in a novel approach.

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